Glucosamine Sulfate: Studies on its Efficacy

Glucosamine Sulfate: Studies on its Efficacy

Debra Murray


Glucosamine sulfate is a chemical that naturally occurs in the body. It's found in the fluid that serves as the cushioning for joints. Without this fluid, the joints begin to painfully grind against each other, similar to pistons in a car engine that's low on oil. This causes a myriad of symptoms such as joint pain, stiffness and swelling, commonly referred to as arthritis or osteoarthritis. Joint disease can affect any part of the body. Since glucosamine sulfate is found in this fluid, it's a natural conclusion that taking a glucosamine sulfate supplement may alleviate joint disease symptoms and slow, or even halt, the progression of joint disease. 


The use of glucosamine sulfate in the treatment of joint disease has been the subject of many studies. In a 2001 study published in "The Lancet," glucosamine sulfate was examined as a treatment for osteoarthritis. The study spanned the course of 3 years and the end result was that the subjects given the glucosamine sulfate had no marked joint degeneration at the end of the study versus the placebo group, which displayed noticeable joint degeneration at the end of the study. 


 In a similar study from "The Journal of Rheumatology," glucosamine sulfate was studied as a treatment for temporomandibular joint disorder versus the standard treatments of ibuprofen and acetaminophen. The subjects were given glucosamine sulfate for 90 days to the study the results. Glucosamine sulfate was found to offer superior treatment as it reduced pain and improved joint function. In addition, it's a superior treatment because it has less side effects than ibuprofen; ibuprofen has been known to cause allergic reactions and has also been implicated in the development of stomach ulcers.  


Finally, a study published in "Drugs & Aging" found that while other varieties of glucosamine, such as glucosamine hydrochloride have no proven application in the treatment of joint disease, there is compelling evidence that glucosamine sulfate has the potential to interfere with the progression of osteoarthritis. 


Glucosamine sulfate is an all-natural remedy to repair damage caused by joint disease. It not only provides treatment, but it also has few side effects. In addition, studies have found positive results from taking it. Glucosamine sulfate might be what stands in the way of possible joint replacement surgery in the future. 


Studies (most notably the GAIT study) have shown that the sulfated forms of glucosamine are more effective than glucosamine bound to hydrochloride (HCl). In addition,  at BLUESPRING we use “fully reacted" forms of glucosamine sulfate. This is the result of combining glucosamine HCl with potassium sulfate to form glucosamine sulfate. 


Many products on the market only mix these two compounds into a tablet or capsule and “assume” the reaction will occur. Testing shows that this does not always happen!


This is why Joint Support is superior. It provides key tested nutraceuticals to help facilitate cartilage building, provide antioxidant support and support a healthy inflammatory response.


GAIT Study; Glucosamine/Chondroitin Arthritis Intervention Trial (GAIT), Conducted by the National Center for Complementary and Alternative Medicine at the National Institute of Health, NIH, NIH GAIT Study Supports Use Of Glucosamine And Chondroitin For Osteoarthritis Treatment. June 2010. 



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